TNFR2 Agonism for Treg Expansion: Why Has the TNF Superfamily Agonism in the Clinic Been So Difficult to Achieve?
Time: 10:00 am
day: Conference Day One AM
Details:
- Exploring why agonism to TNF superfamily receptors has been historically difficult to achieve
- Highlighting new structural biology work, suggesting the ADCC mechanism of antibody agonism may not optimize in vivo clinical effects
- Discovering new structural biology data on hexagonal networks stabilized by antibodies, providing a potential new mechanism for improved clinical outcomes
