Treg Biology Focus Day
Tuesday, March 25, 2025
8:00 am Check-In & Coffee
8:55 am Chair’s Opening Remarks
Exploring Treg Biology to Better Understand Mechanisms of Action
9:00 am Clarifying Treg Function & Behavior to Enhance Therapeutic Development
Synopsis
- Exploring the mechanisms involved in Treg generation
- Examining the role of Tregs in controlling and reversing the inflammatory response to identify new therapeutic opportunities
- Analyzing Treg behavior in different tissues to improve therapeutic efficacy in a variety of disease indications
9:30 am Analyzing the Q/E CD8+ Treg Pathway to Unlock Effective Clinical Applications
Synopsis
- Unravelling the unique mechanisms of the Q/E CD8+ Treg pathway
- Detailing preclinical studies in animals and non-clinical ex vivo studies in humans
- Analyzing safety and efficacy in newly completed phase I/II clinical trials in T1D
- Exploring platforms of drug production and precision assay systems production platforms to ensure precision assay systems
10:00 am Morning Break & Networking
Examining the Top Challenges in Early-Stage Treg Discovery & Drug Development
11:00 am Roundtable Discussion: Exploring Strategies for Treg Tracking & Persistence Analysis
Synopsis
- Discussing tracking techniques to aid in identifying Treg migration and longevity
- Identifying opportunities for strategic optimization
- Identifying effective Treg persistence and functionality biomarkers to enhance persistence analysis
12:00 pm Roundtable Discussion: Reflecting Upon Key Obstacles in Preclinical Treg Research & Discovery
Synopsis
- Exploring difficulties in effectively utilizing preclinical models in research
- Addressing phenotypic uncertainties when identifying and characterizing Tregs to enhance accurate identification
- Understanding Treg Plasticity between regulatory and inflammatory phenotypes to prevent the change of Tregs to T effector cells
- Considering the specificity and selectivity limitations of Tregs therapies
1:00 pm Lunch Break & Networking
Highlighting New Ground-Breaking Data Exploring Tregs in the Brain
2:00 pm Unveiling Innovative Preclinical Meningeal Treg Research to Supercharge Therapeutic Development
Synopsis
- Exploring the Treg population in the meninges in mouse and humans
- Navigating Treg tolerogenic mechanism in the meninges
- Discussing Treg/INF-γ regulation (inflammation)
- Evaluating Treg/B-cells and plasma cell control
- Discovering how meningeal Tregs change in neurodegenerative diseases (AD) in mouse and human