Roberto Gedaly
Professor of Transplant Surgery University of Kentucky
Roberto Gedaly, MD, is a transplant surgeon and clinician-scientist recognized for his work in liver resection, transplantation, and infectious complications such as hepatitis. His research focuses on immunosuppressive strategies in liver transplantation and identifying biomarkers and prognostic indicators in hepatocellular carcinoma to advance effective therapies. Dr. Gedaly earned his medical degree from Universidad Central de Venezuela and completed multiple fellowships in transplantation at Harvard, the University of Miami, and the University of Tennessee. Since joining the University of Kentucky in 2006, he has authored numerous publications and is an active member and invited speaker in global medical societies. He is co-founder and Chief Medical Officer of TOLERAS LLC.
Seminars
- Objective & Innovation: Introducing a novel strategy using normothermic machine perfusion (NMP) as a platform for organ-directed delivery of Treg cells prior to transplantation
- Methodology: Developing proprietary reagents for rapid activation of Treg cells and perfusate enhancement to preserve Treg functionality and support liver metabolic stability during the NMP procedure
- Key Findings: Successful procedural efficacy (Treg infiltration) and organ (liver) functional integrity after NMP/Treg treatment
- Clinical Implications: Establishing a new therapeutic niche for organ-specific cellular immunotherapy prior to transplantation, with the potential to reduce reliance on long term systemic immunosuppression
