Jamie Spangler
Associate Professor, Biomedical & Chemical & Biomolecular Engineering The Johns Hopkins University
Jamie Spangler, Ph.D., is the William R. Brody Faculty Scholar and Associate Professor of Biomedical Engineering and Chemical & Biomolecular Engineering at Johns Hopkins University, where she directs the Spangler Lab and serves as Director of PhD Studies. Her research integrates structural biophysics, biomolecular engineering, and immunology to engineer novel protein therapeutics, including antibody-based molecules that modulate immune cell behavior for cancer, infectious disease, and autoimmune therapies. She earned her B.S. from Johns Hopkins, Ph.D. from MIT, and completed postdoctoral training at Stanford. Dr. Spangler is a 2025 Protein Science Young Investigator and Curtis W. McGraw Research Award recipient.
Seminars
- Apply structural and mechanistic insights to create cytokine/antibody fusion proteins that direct IL-2 activity towards Tregs
- Elucidate key design principles critical to the functional behavior of IL-2-based cytokine/antibody fusion proteins
- Demonstrate translational potential of cytokine/antibody fusion proteins in preclinical models of colitis and hemophilia
