NEW DATA: Engineering Cytokine Bias to Enhance Precise Treg Targeting & Expansion
- Apply structural and mechanistic insights to create cytokine/antibody fusion proteins that direct IL-2 activity towards Tregs
- Elucidate key design principles critical to the functional behavior of IL-2-based cytokine/antibody fusion proteins
- Demonstrate translational potential of cytokine/antibody fusion proteins in preclinical models of colitis and hemophilia