NEW DATA: Development of a Novel Normothermic Machine Perfusion-Based Approach for Treg Cell Therapy in Organ Transplantation
- Objective & Innovation: Introducing a novel strategy using normothermic machine perfusion (NMP) as a platform for organ-directed delivery of Treg cells prior to transplantation
- Methodology: Developing proprietary reagents for rapid activation of Treg cells and perfusate enhancement to preserve Treg functionality and support liver metabolic stability during the NMP procedure
- Key Findings: Successful procedural efficacy (Treg infiltration) and organ (liver) functional integrity after NMP/Treg treatment
- Clinical Implications: Establishing a new therapeutic niche for organ-specific cellular immunotherapy prior to transplantation, with the potential to reduce reliance on long term systemic immunosuppression