Engineering Cytokine Bias to Enhance Precise Treg Targeting & Expansion

11:45 am - Tuesday 24th March 2026

  • Apply structural and mechanistic insights to create cytokine/antibody fusion proteins that direct IL-2 activity towards Tregs
  • Elucidate key design principles critical to the functional behavior of IL-2-based cytokine/antibody fusion proteins
  • Demonstrate translational potential of cytokine/antibody fusion proteins in preclinical models of colitis and hemophilia

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Speakers:

Jamie Spangler
Associate Professor, Departments of Biomedical and Chemical and Biomolecular Engineering
The Johns Hopkins University