Company: University of Pennsylvania
Job title: Professor
Wayne W. Hancock is a Professor of Pathology and Laboratory Medicine at the University of Pennsylvania and Chief of the Division of Transplant Immunology at The Children’s Hospital of Philadelphia. He has long-standing interests in transplant immunobiology and currently focuses on understanding the biology of Foxp3+ Tregs, with the hope that biochemical, pharmacologic and epigenetic studies of murine and human Tregs might lead to practical ways to promote their activities and thereby maintain optimal allograft survival and functions as we’ll as allowing new approaches to the therapy of autoimmune diseases.
Pharmacologic Approaches to Enhance Foxp3+ Treg Production & Function in Autoimmunity & Transplantation 3:30 pm
Our genetic and pharmacologic studies show that Foxp3 is subject to post-translational modifications such as cetylation/deacetylation, ubiquitination/ deubiquitination and phosphorylation/dephosphorylation. Small molecules that increase Foxp3 stability and/or function can be used to promote Treg function in the context of autoimmunity or transplantation Small molecules offer considerable advantages over Treg cell therapy, including cost, convenience, ability…Read more
day: Day Two