Company: Northwestern University
Job title: Professor
My research for the past 30 years has been in the areas of immune responsiveness and tolerance in clinical organ transplantation. The major thrust has been on the immunological effects of donor bone marrow and hematopoietic stem cell infusions in transplant patients. More recent studies have been on the differential susceptibility of CD4+CD127–CD25High FOXP3+ regulatory T cells (Tregs) to various immunosuppressive drugs currently used in clinical transplantation. Another key focus is on the use of polyclonally and donor-specifically expanded autologous Tregs for tolerance induction in clinical transplantation, autoimmunity and allergic diseases.