David Klatzmann

David Klatzmann

Company: University of Pierre & Marie Curie

Job title: Professor

Bio:

As a Professor of Immunology and Director of the Biotherapy Department at the Pitié-Salpêtrière hospital and Pierre and Marie Curie medical school, my main activities have been to advance translational research in Immunology.

I built-up a global organization that is one of the rare structure capable of developing biotherapies from bench to bedside. My current specific interests and research activities are:

Fundamental immunology

I study the development, homeostasis and function of T cells, with a special focus on regulatory T cells (Treg) and systems immunology approaches.

Physiopathology

I study the role of Treg in cancer, inflammation and autoimmunity.

Biotherapy         

I develop various biotherapies, notably biological and cellular Treg-based immunotherapies

Seminars:

IL-2 & Treg Cell Therapies: In or Out? 1:00 pm

IL-2 is the key cytokine for Treg survival and function Treg cell products are cultured in ultra-high dose of IL-2, becoming IL-2 addicted, which impacts their survival and function in patients We generated IL-2 sufficient super-Tregs expressing either wild type or mutated IL-2 under various promoters These cells survive in IL-2 deprived environments and have…Read more

day: Day Two

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