Using a “Trojan Horse” Approach to Restore Treg Function in Autoimmune Diseases

Time: 2:00 pm
day: Day Two | Track B | Afternoon


  • Restoring function to Tregs using small molecules attached to an IL-2 fusion protein to restore function in existent Tregs, not simply increase the number of defective Tregs
  • Presenting results of a mouse derived PDC composed of a fusion protein of murine IL-2 and thioredoxin, to which is attached neddylation activating enzyme inhibitors to restore defective Treg signaling to treat mouse
    autoimmune disease models and asthma
  • Testing a human homologue with two different linkers and two different small molecule drugs to identify a lead drug candidate for development to use in therapy of
    human autoimmune diseases