Pharmacologic Approaches to Enhance Foxp3+ Treg Production & Function in Autoimmunity & Transplantation
Time: 3:30 pm
day: Day Two
- Our genetic and pharmacologic studies show that Foxp3 is subject to post-translational modifications such as cetylation/deacetylation, ubiquitination/ deubiquitination and phosphorylation/dephosphorylation.
- Small molecules that increase Foxp3 stability and/or function can be used to promote Treg function in the context of autoimmunity or transplantation
- Small molecules offer considerable advantages over Treg cell therapy, including cost, convenience, ability to treat repeatedly and/or indefinitely and most importantly, proven efficacy