Leveraging A Natural Differentiation Pathway of T Regulatory-1 (TR1) Cell to Fuel a Nanomedicine Approach to Treat Autoimmune Disease

Time: 3:30 pm
day: Day One | Track B | Afternoon


  • Showing how T-follicular Helper (TFH) cells can serve as in vivo precursors of TR1 cells in humans and in mice
  • Describing complete differentiation of TR1 effector function, requiring the transcription factor Blimp-1 (Prdm1)
  • Presenting Navacims, a pMHC-II nanomedicine platform to induce TFH expansion and differentiation to immunomodulatory TR1 cells