Leveraging A Natural Differentiation Pathway of T Regulatory-1 (TR1) Cell to Fuel a Nanomedicine Approach to Treat Autoimmune Disease
Time: 3:30 pm
day: Day One | Track B | Afternoon
Details:
- Showing how T-follicular Helper (TFH) cells can serve as in vivo precursors of TR1 cells in humans and in mice
- Describing complete differentiation of TR1 effector function, requiring the transcription factor Blimp-1 (Prdm1)
- Presenting Navacims, a pMHC-II nanomedicine platform to induce TFH expansion and differentiation to immunomodulatory TR1 cells
