IL-2 & Treg Cell Therapies: In or Out?

Time: 1:00 pm
day: Day Two


  • IL-2 is the key cytokine for Treg survival and function
  • Treg cell products are cultured in ultra-high dose of IL-2, becoming IL-2 addicted, which impacts their survival and function in patients
  • We generated IL-2 sufficient super-Tregs expressing either wild type or mutated
  • IL-2 under various promoters
  • These cells survive in IL-2 deprived environments and have improved in vitro and in vivo suppressive function
  • IL-2 self-sufficiency should be implemented to improve the potency of any Treg cell therapy, including CAR Tregs