Lilly is a global healthcare leader that unites caring with discovery to create medicines that make life better for people around the world. We were founded more than a century ago by a man committed to creating high-quality medicines that meet real needs, and today we remain true to that mission in all our work. Across the globe, Lilly employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to communities through philanthropy and volunteerism.
TScan Therapeutics is a an engineered TCR-T cell therapy company with a set of proprietary platform technologies that enable the identification of the natural target of a T cell receptor (TCR), as well as the identification of highly active and clinically de-risked TCRs for a desired target and HLA type. This technology can be deployed in the identification of targets and TCRs across multiple therapeutic areas, including autoimmune disorders, cancer, and infectious diseases. TScan’s lead internal TCR-T candidates, TSC-100 and TSC-101, are designed to treat patients with hematologic malignancies, and we are also developing multiplexed TCR-T candidates for the treatment of solid tumors.
To learn more, please visit us at www.tscan.com
We are a revolutionary biotherapeutics company with a mission to revolutionize autoimmune and allergic disease treatment by resetting the immune system for superior long-term disease remission
without the need for chronic dosing and without suppressing the immune system. Our two platform drug candidates, ‘1805 and ‘1104, reset the immune system suppressing only a single administration.
They have demonstrated unique efficacy and safety in preclinical and human studies.
As one of the leading companies in the immune cell therapy with Regulatory T (Treg) cells, TeraImmune is providing innovative Treg cell therapies for the patients with autoimmune diseases. Our proprietary technologies make it possible to consistently produce disease-specific Tregs that retain their suppressive function. TeraImmune is building a solid foundation for Treg cell therapy and aims to conduct a first-in-human study with a ‘FVIII-TCR Treg’ targeting the anti-FVIII antibody formation in severe Hemophilia A.
Harvard Medical School
The Immunobiology Laboratories at Harvard Medical School and Massachusetts General Hospital perform studies on the basic biology TNF superfamily receptors, with an emphasis on autoimmunity and cancer. TNFR2 identifies Treg cells with the highest potency; in human cancers TNFR2 is overexpressed in the tumor microenvironment and in autoimmunity it is under expressed on Tregs. Recent data suggests agonistic TNFR2 antibodies can be made (Science Signaling 2020). For potent TNF superfamily agonism or antagonism, the final surface structures must have either tight hexagonal networks (agonism) or larger
hexagonal networks (antagonism). Humanized antibodies to TNFR2 have now been produced using these principle with broad verification of these desired structural constructs.
Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery.
Thermo Fisher Scientific
As the world leader in serving science, Thermo Fisher Scientific is positioned to provide the quality materials, services and support needed to accelerate the pace of cell and gene therapy development. We understand the complexity of this rapidly evolving industry and have made significant investments in cGMP raw material and drug product manufacturing capabilities to provide innovative workflow solutions. Partner with us to access the high-quality materials, services, and support you need. Through our Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab services, Patheon, and Gibco brands, we offer an unmatched combination of innovative capabilities.