Pre-Conference Bootcamp Day
Tuesday, May 21, 2024
Addressing the Fundamental Role of Tregs in Tissue to Understand the Dynamic Interplay of the Immune Response
9:30 am The Role of Treg Cells in Immune Related Disorders
Synopsis
- Uncover the basics of Treg biology by delving into the mechanisms of Treg immune response suppression
- Examine key signalling pathways (such as CTLA-4 and TGF-β) that mediate Treg suppressive functions to understand potential therapeutic targets
- Gain a comprehensive understanding of Treg-mediated suppression to guide the development of targeted therapies for immune-related disorders
10:00 am Treg Diversity Across Tissues: Implications for Therapeutic Targeting
Synopsis
- Understanding the varying interactions of Treg cells in different tissues within the body
- Discuss how tissue specific Treg populations contribute to immune tolerance
- The implications of tissue specific Treg diversity on the development of targeted therapeutic interventions
10:30 am Morning Break & Refreshments
Exploring the Impact of Treg Biology on Development of Treg Directed Therapies to Drive Precise Therapeutic Interventions
11:00 am Unraveling the Molecular Landscape of Treg Cells: Implications for Therapeutic Development
Synopsis
- Present an in-depth analysis of the molecular mechanisms underlying Treg cell interactions with APC
- Discuss how advanced understanding of Treg biology can inform the design of effective therapeutic strategies
- Exploring potential molecular targets for modulating Treg therapy in the context of therapy development
11:30 am Properties of Therapeutic Nanonparticles
Synopsis
- Provide IL-2 and TGF-β needed for targeted T cells to become Tregs that prevent immune-mediated disease
- Induce – TGF-β producing NK cells that support TregsInduce alloantigen specific Tregs for transplantation tolerance
12:00 pm Integration of Treg Biology & Immunotherapy
Synopsis
- Explore the intersection of Treg biology and immunotherapy, including checkpoint inhibitors and other immune modulators
- Discuss the balance between enhancing immunity and maintaining immune tolerance through Treg-directed interventions
- Highlight case studies and ongoing research initiatives that aim to integrate Treg biology into personalized immunotherapeutic approaches
12:30 pm Lunch
Harnessing the Fundamentals of Treg Biology to Transition into the Clinic for Therapeutic Development
1:30 pm TNFR2 Antagonism in the Tumor Microenvironment
Synopsis
- NFR2 is highly expressed on Tregs in the tumor microenvironment
- TNFR2 has been identified in multiple mechanism tumors use to escape immune surveillance
- TNFR2 plays a role in resistance to checkpoint blockade
- TNFR2 antagonist antibodies have are being tested as monotherapy and combination options in multiple cancers
2:00 pm Revolutionizing Treg Strategies in Oncology: Unraveling the Complexities of Brain Tumors & Cell Therapy
Synopsis
- Treg reprogramming in cancer, particularly brain tumors
- How Tregs influence therapy response to CART (cell therapy) in brain tumors
- How to synergize SoC with Treg targeted therapies in oncology
2:30 pm Novel Mouse Models for the Analysis of Treg Dysfunction in Autoimmunity
Synopsis
- Explore the landscape of Treg dysfunction within autoimmune disease
- Demonstrating a mouse model to knockout the transcription factor helios in Tregs that is restricted to fat involving the destruction of visceral adipose tissue